Los Angeles lies in ruins. While the city is sealed off to contain an unknown contamination, the survivors battle strange anomalies under the toxic dust cloud. Among the survivors are Lee and Branson. The astronaut must find a way out in order not to miss his flight to Cassandra and the captain is faced with a terrible truth that he can no longer deny.

But the horrors in Los Angeles are just a foretaste of what has long since become reality in distant Ulan-Ude in Siberia: the city, sealed off by the Russian military, is lost and with it all its inhabitants. Jenna is one of the last survivors, determined to find out at what has happened there and what machinations are driving the secret organization she is hunting. She doesn't have much time, because Russia wants to get rid of the contamination once and for all.