Tom Butler, the man who saved the world, is dead. The Butler Institute, with all of its wondrous nanotechnology and plans to provide the whole world with food, water, and power, belongs to Noah and his siblings now. All it cost him was his mind, his soul, and one of his brothers.

Guilt, Love, and Other Nanotech Complications continues the story of Noah and the Butler family as the heirs of Tom Butler deal with the aftermath of murdering their father while trying to preserve his plans to save the world. With his heart broken by guilt and his mind broken and patched by the experimental brain implant that allows him to control the unimaginable power of the family's nanotechnology, Noah struggles to carry on the family legacy to preserve life, end suffering, and elevate humanity. He might even do it, if only he can hold together his failing memory, his fragmenting family, and his fading will to live.